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Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 146-161 doi: 10.1007/s11684-014-0373-8

Abstract: The advent of genome-wide association studies (GWAS) has hastened the progress of polygenic obesity researchMoreover, numerous biological studies have been performed on the polygenic effects on obesity, such asstudies on fat mass- and obesity-associated gene (FTO), but the role of these polygenic effects

Keywords： obesity     genetics     genome-wide association studies     body mass index     fat mass- and obesity-associated gene    

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Genome-wide association studies: inherent limitations and future challenges

Yan Du, Jiaxin Xie, Wenjun Chang, Yifang Han, Guangwen Cao

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 444-450 doi: 10.1007/s11684-012-0225-3

Abstract:

Genome-wide association studies (GWAS) have achieved great success in identifying genetic variantsDeep sequencing followed by functional studies will be needed to elucidate the underpinning biological

Keywords： genome-wide association studies (GWAS)     genetic variant     cancer     limitation     challenge    

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Genome-wide association study of the backfat thickness trait in two pig populations

Dandan ZHU,Xiaolei LIU,Rothschild MAX,Zhiwu ZHANG,Shuhong ZHAO,Bin FAN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 91-95 doi: 10.15302/J-FASE-2014005

Abstract: with the tenth rib backfat thickness trait were identified in two independent pig populations, using a genome-wideassociation study of porcine 60K SNP genotype data applying the compressed mixed linear model (CMLM)The results indicated that genetic mechanism regulating backfat thickness is complex, and that genome-wide

Keywords： backfat thickness     SNP chip     genome-wide association study     compressed mixed linear model     pig    

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Genome-wide association analysis reveals genetic loci and candidate genes associated with intramuscular

Xingwang WANG, Rongrong DING, Jianping QUAN, Linxue YANG, Ming YANG, Enqin ZHENG, Dewu LIU, Gengyuan CAI, Zhenfang WU, Jie YANG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 335-341 doi: 10.15302/J-FASE-2017152

Abstract: Genome-wide association study is a powerful tool to detect genomic regions associated with phenotypic

Keywords： Duroc pigs     genome-wide association analysis     intramuscular fat    

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A genome-wide association study of five meat quality traits in Yorkshire pigs

Qian DONG,Huiying LIU,Xinyun LI,Wei WEI,Shuhong ZHAO,Jianhua CAO

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 137-143 doi: 10.15302/J-FASE-2014014

Abstract: To identify genomic regions and haplotype blocks responsible for meat quality traits in pigs, a genome-wideassociation study was conducted for five traits including intramuscular fat content, pH at 45 min and

Keywords： Pig     GWAS     meat quality trait     SNP    

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Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 102-112 doi: 10.15302/J-FASE-2016100

Abstract: provided a great opportunity to explore plant–pathogen interactions from a systems perspective and studiesThen, we focus on reviewing the progress in genome-wide PPI networks related to plant–pathogen interactionsWe anticipate genome-wide PPI network analysis will provide a clearer understanding of plant–pathogen

Keywords： plant–pathogen interactions     systems biology     omics     plant immunity     protein–protein interaction     network    

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Transcriptome resources and genome-wide marker development for Japanese larch (

Wanfeng LI,Suying HAN,Liwang QI,Shougong ZHANG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1,   Pages 77-84 doi: 10.15302/J-FASE-2014010

Abstract: simple sequence repeats, and insertion and deletion markers to assist breeding and genetic diversity studies

Keywords： Larix     transcriptome     age     wood formation     somatic embryogenesis     molecular marker    

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Recent advances in understanding genetic variants associated with economically important traits in sheep (

Song-Song XU, Meng-Hua LI

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 279-288 doi: 10.15302/J-FASE-2017151

Abstract: This review covers recent genome-wide studies on sheep productive traits using high-throughput screeningtechnologies, including those based on single-nucleotide polymorphisms and copy number variants at the whole-genomelevel (e.g., genome-wide association studies), transcriptome and DNA methylation sequences.

Keywords： sheep     high-throughput screening     productive traits     genome-wide studies    

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Twelve Years of Genome-Wide Association Studies of Human Protein N-Glycosylation Review

Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko

Engineering 2023, Volume 26, Issue 7,   Pages 17-31 doi: 10.1016/j.eng.2023.03.013

Abstract: Next, in Section 3, we summarize, systemize, and generalize the results from current N-glycosylation genome-wideassociation studies (GWASs) that provide novel knowledge of the genetic regulation of the populationalUntil now, such studies have been limited to an analysis of the human blood plasma N-glycome

Keywords： Glycome     Glycans     N-glycosylation     Genomics     Genetics     GWAS    

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Genome-wide search for candidate genes determining vertebrae number in pigs

Longchao ZHANG, Jingwei YUE, Xin LIU, Jing LIANG, Kebin ZHAO, Hua YAN, Na LI, Lei PU, Yuebo ZHANG, Huibi SHI, Ligang WANG, Lixian WANG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 327-334 doi: 10.15302/J-FASE-2017163

Abstract: A genome-wide association study (GWAS) identified 36 significant single nucleotide polymorphisms (SNPsHowever, the reported putative casual mutation of c.748C>T showed no genome-wide significant associationExploration of these genes via additional genetic and functional studies in mammals revealed that could

Keywords： genome-wide association study     number of vertebrae     pig     SSC7     TGFβ3    

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Genome-wide identification and expression analysis of the β-amylase genes strongly associated with fruit

Hongxia MIAO,Peiguang SUN,Yulu MIAO,Juhua LIU,Jianbin ZHANG,Caihong JIA,Jingyi WANG,Zhuo WANG,Zhiqiang JIN,Biyu XU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 4,   Pages 346-356 doi: 10.15302/J-FASE-2016127

Abstract: This study identified 16 genes in the banana genome.transcriptional characteristics of the genes in banana and may serve as a basis for further functional studies

Keywords： β-amylase     banana     genome-wide identification     fruit development     abiotic stress    

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The predictive value of chromosome 8p deletion for metastasis of hepatocellular carcinoma: a summary of works in 10 years

QIN Lunxiu, TANG Zhaoyou, GUAN Xinyuan, YE Qinghai, JIA Huliang, REN Ning

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 211-215 doi: 10.1007/s11684-008-0041-y

Abstract: By the more sensitive genome-wide microsatellite analysis, 8p deletion was defined to 8p23.3 and 8p11.2Clinical studies indicate that 8p deletion detected in HCC or circulating plasma DNA of patients is a

Keywords： sensitive genome-wide     prediction     genome-wide microsatellite     frequency     Hepatocellular carcinoma    

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U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 478-486 doi: 10.1007/s11684-015-0420-0

Abstract: Epidemiological studies have suggested that inter-individual differences of telomere length could affecttelomere length-related single nucleotide polymorphisms (TL-SNPs) in Caucasians have been reported in genome-wideassociation studies.More interestingly, an evident nonlinear U-shaped association was observed between RTL and ESCC risk

Keywords： esophageal squamous cell carcinoma     telomere length     genetic variants     susceptibility     genome-wide association    

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Construction, characterization and application of a genome-wide promoter library in

Ting Yuan,Yakun Guo,Junkai Dong,Tianyi Li,Tong Zhou,Kaiwen Sun,Mei Zhang,Qingyu Wu,Zhen Xie,Yizhi Cai,Limin Cao,Junbiao Dai

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 107-116 doi: 10.1007/s11705-017-1621-7

Abstract: Here we report the construction of a genome-wide promoter library, in which each native promoter in

Keywords： synthetic biology     yeast     promoter activity     metabolic engineering     xylose utilization    

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Genome-wide analysis reveals selection for Chinese Rongchang pigs

Lei CHEN, Shilin TIAN, Long JIN, Zongyi GUO, Dan ZHU, Lan JING, Tiandong CHE, Qianzi TANG, Siqing CHEN, Liang ZHANG, Tinghuan ZHANG, Zuohua LIU, Jinyong WANG, Mingzhou LI

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 319-326 doi: 10.15302/J-FASE-2017161

Abstract: To identify selection signatures in the genome of Chinese Rongchang pigs, we generated a total of aboutBy combining these data with the publically available genome data of 10 Asian wild boars, we identifiedvaluable genetic resources that can enhance the use of pigs in agricultural production and biomedical studies

Keywords： domestication     genome     pig     re-sequencing     selection    

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Title Author Date Type Operation

Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Journal Article

Genome-wide association studies: inherent limitations and future challenges

Yan Du, Jiaxin Xie, Wenjun Chang, Yifang Han, Guangwen Cao

Journal Article

Genome-wide association study of the backfat thickness trait in two pig populations

Dandan ZHU,Xiaolei LIU,Rothschild MAX,Zhiwu ZHANG,Shuhong ZHAO,Bin FAN

Journal Article

Genome-wide association analysis reveals genetic loci and candidate genes associated with intramuscular

Xingwang WANG, Rongrong DING, Jianping QUAN, Linxue YANG, Ming YANG, Enqin ZHENG, Dewu LIU, Gengyuan CAI, Zhenfang WU, Jie YANG

Journal Article

A genome-wide association study of five meat quality traits in Yorkshire pigs

Qian DONG,Huiying LIU,Xinyun LI,Wei WEI,Shuhong ZHAO,Jianhua CAO

Journal Article

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Journal Article

Transcriptome resources and genome-wide marker development for Japanese larch (

Wanfeng LI,Suying HAN,Liwang QI,Shougong ZHANG

Journal Article

Recent advances in understanding genetic variants associated with economically important traits in sheep (

Song-Song XU, Meng-Hua LI

Journal Article

Twelve Years of Genome-Wide Association Studies of Human Protein N-Glycosylation

Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko

Journal Article

Genome-wide search for candidate genes determining vertebrae number in pigs

Longchao ZHANG, Jingwei YUE, Xin LIU, Jing LIANG, Kebin ZHAO, Hua YAN, Na LI, Lei PU, Yuebo ZHANG, Huibi SHI, Ligang WANG, Lixian WANG

Journal Article

Genome-wide identification and expression analysis of the β-amylase genes strongly associated with fruit

Hongxia MIAO,Peiguang SUN,Yulu MIAO,Juhua LIU,Jianbin ZHANG,Caihong JIA,Jingyi WANG,Zhuo WANG,Zhiqiang JIN,Biyu XU

Journal Article

The predictive value of chromosome 8p deletion for metastasis of hepatocellular carcinoma: a summary of works in 10 years

QIN Lunxiu, TANG Zhaoyou, GUAN Xinyuan, YE Qinghai, JIA Huliang, REN Ning

Journal Article

U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Journal Article

Construction, characterization and application of a genome-wide promoter library in

Ting Yuan,Yakun Guo,Junkai Dong,Tianyi Li,Tong Zhou,Kaiwen Sun,Mei Zhang,Qingyu Wu,Zhen Xie,Yizhi Cai,Limin Cao,Junbiao Dai

Journal Article

Genome-wide analysis reveals selection for Chinese Rongchang pigs

Lei CHEN, Shilin TIAN, Long JIN, Zongyi GUO, Dan ZHU, Lan JING, Tiandong CHE, Qianzi TANG, Siqing CHEN, Liang ZHANG, Tinghuan ZHANG, Zuohua LIU, Jinyong WANG, Mingzhou LI

Journal Article